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TFOS DEWS II Framework

AN UNSTABLE TEAR FILM PLANS AN UNSTABLE SURGERY.

Written by the RLES AI clinical rules team · Medically reviewed by Fırat Helvacıoğlu, MD · Alim Hüseynov, MD · Last updated: 24 August 2026

Untreated dry eye corrupts the very measurements a plan is built on — and predicts the unhappiest post-operative patients. RLES AI supports dry-eye assessment using the TFOS DEWS II framework and screens every incoming topography for tear-film artefacts, whether you asked or not.

ASSESSMENT WITH TWO ARMS, NOT ONE SCORE

DEWS II requires both a symptom arm (OSDI ≥ 13 or DEQ-5 ≥ 6) and at least one homeostasis marker — tear break-up time under 10 seconds, osmolarity ≥ 308 mOsm/L or an inter-eye difference over 8, or significant staining.[2] One arm alone is graded BORDERLINE, and a symptomatic patient with clean signs is flagged for the neuropathic/preclinical distinction rather than dismissed. Subtyping (aqueous-deficient, evaporative-MGD, mixed)[1] follows Schirmer and meibomian findings — MGD being the most common substrate — and results are recorded with their values, never as "done, normal".

THE SILENT SCREEN ON EVERY TOPOGRAPHY

  • Mire distortion, inter-acquisition Sim-K discordance over 0.25 D, unstable axes
  • False-keratoconus patterns: inferior steepening that migrates between acquisitions, resolves with artificial tears, and leaves the posterior surface untouched — unmasked before it triggers a wrong ectasia verdict
  • Two or more signatures → a yellow block, and borderline anterior indices are no longer counted as keratoconus evidence on that map

THE GATE: STABILISE, THEN PLAN

Moderate-to-severe disease is a relative contraindication: staged treatment first, re-evaluation in 2–4 weeks, and no ablation finalised until two consecutive concordant topographies confirm a stable surface. Method notes are included — flap-based LASIK cuts more corneal nerves than SMILE, and hinge position matters for the ocular surface.

FREQUENTLY ASKED QUESTIONS

Why screen the tear film before laser surgery?
An unstable tear film distorts topography — it can fake keratoconus patterns and corrupt the maps a plan is built on — and untreated dry eye is the strongest predictor of chronic post-operative dry eye.
Which framework does the analysis follow?
TFOS DEWS II: a symptom arm plus at least one homeostasis marker, with subtype (aqueous-deficient, evaporative/MGD, mixed) and severity grading.
SEE IT ON YOUR OWN CASES.
RLES AI runs as a mobile interface on your phone — nothing to install from a store, reports in minutes. The final clinical decision always rests with the surgeon.

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References — peer-reviewed sources
  1. Craig JP et al. TFOS DEWS II Definition and Classification Report. Ocul Surf 2017;15:276-83. PMID: 28736335
  2. Wolffsohn JS et al. TFOS DEWS II Diagnostic Methodology report. Ocul Surf. 2017;15(3):539-574. doi:10.1016/j.jtos.2017.05.001 PMID: 28736342
Sources open on PubMed in a new tab.